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These recorded presentations describe research technologies and techniques that utilize optical molecular imaging. Watch them any time when it’s convenient for you to learn how you can improve and extend your research. |
| To review the complete abstract for any of our webinars below, click on the title link. You will also be able to access the Webinar from the abstract page after entering basic contact information. |
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Upcoming Webinars |
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Date & Time: Wednesday, September 22nd - 1pm EDT
Topic: X-Ray Imaging Of Vascular Density In Mice
Abstract: The goal of angiography is to study and visualize structural abnormalities in the vascular system. In traditional angiography, a radio opaque contrast is injected intravascularily and X-rays are used to visualize the vasculature. The most common radio opaque contrasts used in radiology are Iodine and Barium sulfate. Barium sulfate is highly cost effective and is routinely used to study gastro intestinal tract abnormalities.
In this webinar, we will discuss the barium contrast angiogram technique using an X-ray source to acquire the high resolution images of the vasculature, which would be otherwise be obtained by expensive CT angiograms. We investigated the vascular heterogeneity in various vascular beds in different transgenic mice. This technique can be applied to visualize gross structural abnormalities in major vessels, such as aortic dissection, as well as in cancer studies.
The use of barium sulfate with an X-ray system in this technique is highly cost effective and can be readily used in post-mortem angiography experiments.
What should attendees expect to learn:
• Technique of angiography using barium contrast
• Assessment of vascular structural abnormalities
• Pros and cons of barium contrast angiography
Who should attend - Researchers interested in:
• Studying vascular structural abnormalities
• Using cost effective angiograms
Speaker:
Dr. S. Givvimani
Department of Physiology and Biophysics,
University of Louisville School of Medicine,
Louisville, KY.
Register On-Line
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Recorded Webinars
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• Opportunities and Challenges of Imaging Antibodies In Vivo using Pre-clinical Small Animal Models
Researchers routinely use antibodies to visualize protein expression in ex vivo and in vitro samples. Western blots and immunohistochemistry are the top two applications for utilizing these approaches. Antibodies are relatively amenable to chemical conjugation of fluorophores and radiotracers, and can be purchased as pre-labeled compounds. Given the widespread availability of high quality antibodies, why haven’t they been used for in vivo research in a systematic way? In this webinar, we intended to highlight the challenges posed by utilizing antibodies in vivo, but also highlight key applications where antibodies can successfully be used in small animal models.
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• Utilizing A High Resolution X-Ray System For Basic And Pre-Clinical Research
The skeleton is scaffold upon which our bodies and many other animals are built. A number of disorders affect the skeletal system including developmental disorders, acute injuries, and metastatic bone cancer. Pre-clinical small animal models exist for many of these bone disorders. These models can serve as a platform for studying other genetic modifiers or potential therapeutics. However, conducting these studies often require sacrifice of the animals, dissection, and study via microscopy or X-vivo CT analysis. By contrast, non-invasive imaging provides a resource for conducting longitudinal studies without sacrificing or harming the animal. In this webinar, we shall demonstrate how quantitative, small animal X-ray systems provide an ideal solution for non-invasive imaging a both the skeleton or soft tissue structures in pre-clinical animal models.
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• Non-Invasive In Vivo Imaging of Cell Death via Apoptosis or Necrosis
How do cells decide whether to live or die? Answering this seemingly simple question has engaged researchers across a variety of disciplines including neuroscience, pharmacology, oncology, cardiology, and development. Much of this work answering these questions has been necessarily studied in model organisms and in cultured cells. Yet the most critical questions involving cell fate often require the necessarily complex environment of a living animal such as a mouse or rat. Paracrine and autocrine signals as well as relative immunological response and 3D structure often play a decisive role in the fate of cells in live animals, and many of these conditions are difficult to replicate in vitro. |
• Fully Automated Digital Imaging: Introducing the Gel Logic 2200PRO
The Gel Logic 2200 PRO is the new automated workhorse of the Gel Logic imagers. Aimed at the entry level luminescent imaging market, the GL 2200 PRO offers integrated trans-UV and trans-white light illumination for versatile imaging of protein and DNA based gels. Cooling the GL 2200 PRO to -29C (abs) allows luminescent imaging of western blots, luminescent plate assays. Automated controls adjust and optimize the lens focus, FOV, f-stop, and exposure of the sample, simplifying image capture and workflow. |
• Introducing the Albira System - A Revolutionary PET/SPECT/CT Combination
The Albira system combines PET, SPECT, and CT imaging in six novel and extremely powerful ways. The system’s highly compact, multi-modal modular design gives you the freedom to purchase what you need now, and upgrade as you research needs evolve. |
• Multimodal Optical and Nuclear Imaging
Preclinical applications of biomedical imaging are rapidly expanding as tools for molecular biology research and diagnostic contrast agent development. As no single imaging modality can provide a full picture of the complex biology of disease, more researchers are turning to multimodality imaging. The availability of contrast agents for optical and nuclear imaging has never been higher, including both genetically engineered reporters and synthetic compounds. In this webinar, we will discuss the principles of planar optical imaging and scintigraphy in the context of imaging in animal models. These techniques are economical and simple, allowing facile data co-registration. We will review multimodal imaging strategies with respect to laboratory research and clinical applications |
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• Taking Your First Step into Digital Imaging: The Gel Logic 112
The Carestream Gel Logic 112 is designed for research labs who want a simple, inexpensive solution to everyday imaging needs. The 112 is a high quality, cost effective documentation device that allows you to easily and quickly image gels (both protein and nucleic acid), blots, plates, assays, and other in vitro specimens.
Our easy to use graphical interface allows lab personnel to start capturing quality images immediately, without the need to devote a majority of time towards mastering the software. It is designed for a wide range of applications ranging from band densitometry to color/image enhancement.
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• "KODAK X-SIGHT Large Stokes Shift Dyes: One Dye, One Optimization, from In Vitro to In Vivo"
In this webinar, we will demonstrate how a novel near-IR (NIR), Large Stokes Shift (LSS) fluorophore is capable of spanning the in vitro and in vivo space. In addition, we will discuss how the combination of NIR and LSS properties enhances signal-to-noise ratios by minimizing background. We will also discuss how the LSS dye provides flexibility to accommodate a multitude of filter sets that are common to most equipment. |
• "Optical Imaging of Anionic Membranes for Detecting and Monitoring Disease States In-Vivo"
In this webinar, we will discuss the development of a series of fluorescent probes, each composed of synthetic zinc (II)-dipicolylamine affinity ligand conjugated to a near-infrared dye. These small molecule probes can target anionic membranes, permitting detection of bacterial infection, tumors, and tissue damage in living animals. |
• "Using TEM Film Today"
In this webinar, we will review when it is advantageous to use film in particular imaging situations. Discussions will also include using film in conjunction with digital imaging to provide optimum image quality results, while maintaining a productive work flow |
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• "Introducing Carestream Molecular Imaging’s New Bone Density Software"
Carestream is pleased to announce the release of our newest accessory for our advanced MI Software. With this powerful new addition, you can now perform bone density and bone mass analysis of small animals in vivo and mineral density of in-vitro specimens.
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• "Getting the Most from Your Display, Analysis, and Reporting Features using Carestream/Kodak Molecular Imaging Software "
This presentation will review the wide range of image display, analysis, and reporting tools that uniquely complements the capture output of molecular imaging systems |
| • "Introduction to Optical Imaging for Investigating Cancer Biology and Relevant Pathways" Recently, near-infrared and red fluorescent probes have enabled significant advances in understanding the role of proteins and enzymes in tumor biology in-vivo |
| • "The Next Evolution in Gel Documentation Systems: Introducing the Gel Logic 212 PRO" This webinar will introduce Carestream Molecular Imaging's next-generation gel documentation system, the new, fully automated Gel Logic 212 PRO |
| • "Visible to Near-IR Fluorescent Imaging and Labeling Tools for in vitro and in vivo Applications" Well-refined molecular imaging tools contribute considerably to the progress made in understanding the function of bio-molecules in vitro and their interactions in vivo |
